Department of Biochemistry and Molecular Biology
|Degree Name||Group/Major Subject||Board/Institute||Country||Passing Year|
|Title||Organization||Location||From Date||To Date|
|Professor||Dhaka University||Dhaka, Bangladesh||08, Oct 2019||Currently Working|
|Treasurer and Vice Chancellor (Acting)||Barishal University||Barishal, Bangladesh||25, Jun 2019||07-10-2019|
|Treasurer and Vice Chancellor (Acting)||Barishal University||Barishal, Bangladesh||11, Apr 2019||26-05-2019|
|Treasurer and Vice Chancellor (Acting)||Barishal University||Barishal, Bangladesh||05, Aug 2018||30-08-2018|
|Treasurer and Vice Chancellor (Acting)||Barishal University||Barishal, Bangladesh||01, Jun 2017||30-06-2017|
|Treasurer and Vice Chancellor (Acting)||Barishal University||Barishal, Bangladesh||16, Jun 2016||15-07-2016|
|Treasurer||Barishal University||Barishal, Bangladesh||08, Oct 2015||07-10-2019|
|Professor||Dhaka University||Dhaka, Bangladesh||10, Oct 2013||07-10-2015|
|Associate Professor||Dhaka University||Dhaka, Bangladesh||23, Jun 2011||09-10-2013|
|Assistant Professor||Dhaka University||Dhaka, Bangladesh||01, Apr 2011||22-06-2011|
|Assistant Professor||Kyoto Sangyo University||Kyoto, Japan||01, Apr 2010||31-03-2011|
|Visiting Associate Professor||Kobe University||Kobe, Japan||01, Jun 2008||31-03-2010|
|Assistant Professor||Dhaka University||Dhaka, Bangladesh||29, Nov 2006||31-05-2008|
|Lecturer||Dhaka University||Dhaka, Bangladesh||01, Mar 2001||28-11-2006|
|Research Officer||icddr,b||Dhaka, Bangladesh||14, Mar 2000||13-02-2001|
|Subject||Description||Research Interest (Goal, Target Indicator)|
|Industrial microbiology (Essential amino acids)||
Amino acids, whose carbon skeletons are not synthesized de novo by animal and human cells, must be provided in diets to sustain life and therefore, are nutritionally essential. Of the 20 standard proteinogenic amino acids, the nine are essential amino acids (EAAs). Of the nine EAAs, L-valine, L-leucine and L-isoleucine are branched-chain amino acids (BCAAs). Amino acids have many potentials uses as animal feed supplements, food additives, and materials for cosmetics, pharmaceuticals, and polymers. In addition, BCAAs have been used in ill patients’ therapy, as a precursor of antibiotics and herbicides, and in physiology. We previously tried to isolate bacteria from environmental sample that can produce amino acid and our specific focus was on L-Met. Due to time limit and lack of funding, this research was poorly progressed. The new research plan has been designed to isolate, screen, and characterize the branched chain essential amino acid (BCEAA) producing bacteria from environmental sample. The long-term plan is to optimize the production of BCEAAs and to purify them for commercialization. Later, the research plan will also be designed for other essential amino acids as well.
|Industrial microbiology (Carotenoids)||
Carotenoids are a group of yellow, orange-red-pigmented isoprenoids that are naturally synthesized by plants, algae, cyanobacteria, bacteria, and fungi. Naturally isolated carotenoids could be applied industrially in food, feed, cosmetic, and pharmaceutical product formulations alternative to chemically synthesized one. Colour pigment producing microorganisms hold a promising potential to meet the present-day challenges. Thus, scientific interest is growing rapidly to isolation and purification of carotenoids from the natural sources. Our initial research that had been designed to isolate, screen and characterize the bacterial isolate that can produce different types of colour pigments/carotenoids. We characterized the bacterial isolate up to the genus level. Our aim was also to extract carotenoids and to run them in HLPC to observe the available peak(s). We have selected three bacterial isolates for further study. The present short-term objective is to optimize the bacterial growth changing its medium and growth conditions, to efficient extraction of carotenoids using different mixture of extracts and to identify all peaks observed in HPLC. The long-term objective is to purify the carotenoids in laboratory to industry scale for commercialization.
The understanding of occurrence and the treatment to cure cancer are still daunting task. Everyday new data is generating and research is going on this life-threatening disease. The data for understanding of micronutrients association with various types of cancers is still accumulating. Recently, we have investigated the associations of vitamins (A, D and E), and minerals (calcium, magnesium, iron, and zinc) to bladder, ovary and breast cancer. It was found that there is correlation between micronutrients status and such type of cancer occurrence. We have planned to extent and specifically elaborate our thinking on bladder cancer. Because the different degree of expression of uroplakin III (UPIII), a transmembrane protein, is involved in bladder cancer aggressiveness. The diagnostic value of plasma and urine uroplakin IIIa (UPIIIa) levels in bladder cancer could be early and non-invasive approach in bladder cancer diagnosis. We have also shown the involvement and role of UPIII in sperm-mediated egg activation, a prerequisite priming for successful fertilization. Thus, to me, UPIII is a molecule that play not only in the beginning of life but also in the deadly disease cancer to threaten life.
|Level of Study||Title||Supervisor||Co-Supervisor(s)||Name of Student(s)||Area of Research||Current Completion|
|Masters||Screening and characterization of antibiotic resistant bacteria isolated from vegetables and farm products.||Professor Dr AKM Mahbub Hasan||Tamara Tasbiha||2015|
|Masters||Screening and characterization of amino acid producing bacteria isolated from different environmental samples.||Professor Dr AKM Mahbub Hasan||Nipa Akter||2015|
|Masters||Prediction of unique identifiers in 95 indigenous rice landraces in Bangladesh.||Professor Dr AKM Mahbub Hasan||Professor Dr Zeba I Seraj||Afroza Ferdouse||2014|
|Masters||Investigation of antimicrobial efficacy of lantibiotics, nisin to multidrug resistant (MDR) Mycobacterium tuberculosis.||Professor Dr AKM Mahbub Hasan||Dr Md Riazul Islam||Mahfuzur Rahman||2014|
|Masters||16S rRNA sequence based identification of pathogenic gut microbiota of rohu Labeo rohita (Hamilton‐Buchanan 1822) and silver carp Hypophthalmichthys molitrix (Valenciennes 1844).||Dr Wahida Haque||Professor Dr AKM Mahbub Hasan, Dr Mohammad Shamsur Rahman||Nusrat Jahan Punom||2014|
|Masters||Screening of antibiotic resistance bacteria isolated from vegetables and eggs.||Professor Dr AKM Mahbub Hasan||Nusrat Sharmin Shimly||2014|
|Masters||Molecular characterization of a dehairing bacteria and Isolation, purification and characterization of its extracellular protease enzyme.||Dr AKM Mahbub Hasan||Md Habibur Rahman||2011|
|Masters||Identifying unique identifier among the rice landraces of Bangladesh.||Dr AKM Mahbub Hasan||Professor Dr Zeba I Seraj||Nusrat Yesmin||2011|
|Masters||Isolation and biochemical characterization of unknown dehairing bacteria and its extracellular protease enzyme.||Dr AKM Mahbub Hasan||Md Firoz Mortuza||2006|
|Masters||Microsatellite marker and sequence variability for determination of genetic diversity and polymorphism in the red rice populations of Bangladesh.||Dr AKM Mahbub Hasan||Professor Dr Zeba I Seraj||Sabrina M Elias||2006|
|Subject||Project Name||Source of Fund||From Date||To Date||Collaboration|
|Industrial microbiology||Isolation and characterization of plastic degrading microorganisms from soil and their capacity to degrade plastic materials.||UGC, Bangladesh||01-07-2019||30-06-2020||PI: Dr Rehana Parvin, Co-PI: Professor Dr AKM Mahbub Hasan, Professor Dr Md Rakibul Islam|
|Population genetics||Determination of calcium homeostasis and genetics with respect to SLC25A12 and SLC25A13 genes in autism spectrum disorders.||MOST, Bangladesh||01-07-2019||30-06-2020||PI: Professor Dr AHM Nurun Nabi, Co-PI: Professor Dr AKM Mahbub Hasan|
|Cancer biology||Analysis of micronutrients levels in cancer patients of Bangladesh.||UGC-BU, Bangladesh||01-07-2018||30-06-2019||PI: Dr Rehana Parvin, Co-PI: Professor Dr AKM Mahbub Hasan|
|Industrial microbiology||Biotechnological production of carotenoids from bacteria for feed and food industry.||MOE, Bangladesh||01-07-2018||30-06-2020||PI: Professor Dr Md Rakibul Islam, Co-PI: Professor Dr AKM Mahbub Hasan|
|Population genetics||Association study of type 2 diabetes with telomere length and telomerase gene polymorphism in Bangladeshi Population.||TWAS, Italy||01-01-2016||31-12-2016||PI: Professor Dr AHM Nurun Nabi, Co-PI: Professor Dr AKM Mahbub Hasan|
|Population genetics||Association study of mitochondrial DNA copy number and polymorphisms with type 2 diabetes: Development of a mitochondrial DNA database of Bangladeshi population.||MOE, Bangladesh||01-07-2015||30-06-2017||PI: Professor Dr AHM Nurun Nabi, Co-PI: Professor Dr AKM Mahbub Hasan|
|Food microbiology||Screening the prevalence of antibiotic resistant bacteria in human foods and identification of those bacteria and their possible determinants of antibiotic resistance (Extension).||MOST, Bangladesh||01-07-2015||30-06-2016||PI: Professor Dr AKM Mahbub Hasan|
|Microbial genetics||Investigating the potential of Clustered regularly interspersed short palindromic repeats (CRISPR) pathway to limit the spread of antibiotic resistance genes among pathogenic bacterial species.||MOE, Bangladesh||01-07-2014||30-06-2017||PI: Professor Dr M Anwar Hossain, Co-PI: Professor Dr AKM Mahbub Hasan|
|Food microbiology||Screening the prevalence of antibiotic resistant bacteria in human foods and identification of those bacteria and their possible determinants of antibiotic resistance.||MOST, Bangladesh||01-07-2014||30-06-2015||PI: Professor Dr AKM Mahbub Hasan|
|Cancer biology||Analysis of biochemical parameters in cancer diseases.||UGC, Bangladesh||01-07-2014||30-06-2015||PI: Professor Dr AKM Mahbub Hasan|
|Population genetics||Determination of genotypic and allelic frequencies of reactive oxygen species neutralizing enzyme genes and tumor suppressor gene in heavy metal exposed Bangladeshi population.||MOST, Bangladesh||01-07-2013||30-06-2014||PI: Professor Dr AHM Nurun Nabi, Co-PI: Professor Dr AKM Mahbub Hasan|
|Cancer biology||Analysis of vitamins status in serum of cancer patients.||UGC-DU, Bangladesh||01-07-2013||30-06-2014||PI: Professor Dr AKM Mahbub Hasan|
|Public health||Analysis of Arsenic contamination in food grains and vegetables produced in southern part of Bangladesh.||CASRBS-DU, Bangladesh||01-07-2011||30-06-2012||PI: Professor Dr Hossain Uddin Shekhar, Co-PI: Dr AKM Mahbub Hasan|
|Public health||Identification, promotion and popularization of functional foods for additional health benefits: the Bangladesh context.||MOSICT, Bangladesh||01-07-2011||30-06-2012||PI: Professor Dr Hossain Uddin Shekhar, Co-PI: Dr AKM Mahbub Hasan|
|Cancer biology||Uroplakin, a protein, as a marker of human diseases.||CASRBS-DU, Bangladesh||01-07-2011||30-06-2012||Dr AKM Mahbub Hasan|
Keynote speech on Environment related policies in Bangladesh: governance and political perspective. Conference on Environmental Solutions for Sustainable Development: Towards Developed Bangladesh (CESSD 2019). Organized by Forest and Environment Affairs Sub-Committee, Bangladesh Awami League held on November 27-28, 2019.
|SL||Collaboration & Membership Name||Type||Membership Year||Expire Year|
|1||Member of Managing Council||Center for Bioinformatics Learning Advancement and Systematic Training (cBLAST)||2015||2020|
|2||Executive Committee Member||Bangladesh Society for Biochemistry and Molecular Biology (BSBMB)||2015||2020|
|3||Member||Graduate Biochemists Association, Bangladesh (GBA)||1997||Life Time|
|4||Member||Bangladesh Society for Biochemistry and Molecular Biology (BSBMB)||2001||Life Time|
|5||Member||The Molecular Biology Society of Japan (MBSJ)||2008||2010|
|6||Member||The Molecular Biology Society of Japan (MBSJ)||2002||2006|
|7||Member||The Japanese Biochemical Society (JBS)||2008||2010|
AKM Mahbub Hasan, Chakrobarty, S, Chakrobarty, R and Nabi, A.H.M. Nurun. "Application of Biotechnology and Bioinformatics in Drug Designing and Discovery." BIOTECHNOLOGY AND BIOINFORMATICS. In: Devarajan Thangadurai, Sangeetha J. New Jersey: USA: Apple Academic Press, 2014, p355-390 .
Sato KI, AKM Mahbub Hasan and Ijiri T. "Focused Proteomics on Egg Membrane Microdomains to Elucidate the Cellular and Molecular Mechanisms of Fertilization in the African Clawed Frog Xenopus laevis." Sexual Reproduction in Animals and Plants. In: Sawada H, Inoue N, Iwano M. Springer Japan, 2014, p157-170 .
AKM Mahbub Hasan, Takashi Matsumoto, Shigeru Kihira, Junpei Yoshida and Ken-ichi Sato. "Phospho-Signaling at Oocyte Maturation and Fertilization: Set Up for Embryogenesis and Beyond Part II. Kinase Regulators and Substrates." Embryogenesis. Dr. Ken-Ichi Sato (Ed.). InTech, 2012, p499-554 .
AKM Mahbub Hasan, Takashi Matsumoto, Shigeru Kihira, Junpei Yoshida and Ken-ichi Sato. "Phospho-Signaling at Oocyte Maturation and Fertilization: Set Up for Embryogenesis and Beyond Part I. Protein Kinases." Embryogenesis. Dr. Ken-Ichi Sato (Ed.). InTech, 2012, p447-498 .
Goswami A, Huda N, Yasmin T, Hosen MI, AKM Mahbub Hasan and Nabi AHMN : Association study of leukocyte telomere length and genetic polymorphism within hTERT promoter with type 2 diabetes in Bangladeshi population., Molecular Biology Reports , vol.48 , no.1 Springerlink , pp.285-95 , 2021 .
Sajoy Kanti Saha, Jobaida Akther, Nafiul Huda, Tahirah Yasmin, Md. Sohrab Alam, Md. Ismail Hosen, AKM Mahbub Hasan and A.H.M. Nurun Nabi : Genetic association study of C5178A and G10398A mitochondrial DNA variants with type 2 diabetes in Bangladeshi population, Meta Gene , vol.19 , pp.23-31 , 2019 .
Alam Md S, Chakraborty S, Rahman T, Hosen Md I, Paul A, AKM Mahbub Hasan and Hossain MA : Investigation of the Potential Association between Clustered Regularly Interspersed Short Palindromic Repeats (CRISPR) and Antibiotic Resistance Pattern of Bacterial Strains Isolated from Medical Waste and Environmental Water, Open Journal of Medical Microbiology , vol.8 , no.2 , pp.13-25 , 2018 .
Huda N, Hosen MI, Yasmin T, Sarkar PK, AKM Mahbub Hasan and Nabi AHMN : Genetic variation of the transcription factor GATA3, not STAT4, is associated with the risk of type 2 diabetes in the Bangladeshi population, PLoS One , vol.13 , no.7 , pp.e0198507 , 2018 .
Md. Firoz Mortuza, Md. Haﬁzur Rahman, Md. Habibur Rahman, Arifatun Nahar, Md. Rezaul Islam Khan, AKM Mahbub Hasan and Mustaﬁzur Rahman : Isolation, biochemical and genetic characterization of extracellular protease producing cattle hide dehairing bacterium-A potential alternative to chemical dehairing, Ecological Genetics and Genomics , vol.2 , pp.3-12 , 2017 .
Nusrat Jahan Punom, AKM Mahbub Hasan, Wahida Haque, Mst Khadiza Begum and Mohammad Shamsur Rahman : 16S rRNA Sequence Based Identification of Pathogenic Gut Microbiota of Rohu Labeo Rohita (Hamilton‐Buchanan 1822) and Silver Carp Hypophthalmichthys Molitrix (Valenciennes 1844), Dhaka Univ J Biol Sci , vol.25 , no.2 , pp.169‐184 , 2016 .
Amin MA, Islam MB, AKM Mahbub Hasan, Chowdhury EK and Shekhar HU : Pattern of Drug Resistance of Pathogenic Microbes in the Street Foods of Dhaka City, Bangladesh, Biores Comm , vol.1 , no.1 , pp.48-52 , 2015 .
Haque ME, Mahmud Z, AKM Mahbub Hasan, Sardar R and Haque ST : Betulin-3-caffeate and Amyrin from the Stem Bark of Barringtonia acutangula (L), Biores Comm , vol.1 , no.2 , pp.121-123 , 2015 .
Yesmin N, Elias SM, Rahman MS, Haque T, AKM Mahbub Hasan and Seraj ZI : Unique Genotypic Differences Discovered among Indigenous Bangladeshi Rice Landraces, International Journal of Genomics , vol.2014 , pp.210328 , 2014 .
Sakib MS, Islam MR, AKM Mahbub Hasan and Nabi AHMN : Prediction of Epitope-Based Peptides for the Utility of Vaccine Development from Fusion and Glycoprotein of Nipah Virus Using In Silico Approach, Advances in Bioinformatics , vol.2014 , pp.402492 , 2014 .
Hoque MA, Khatun MA, Islam R, Shekhar HU, Haque ME and AKM Mahbub Hasan : Antibacterial Activity of the Organic Extracts of Stem Bark of Cinnamomum aromaticum Nees, Dhaka Univ J Pharm Sci , vol.13 , no.2 , pp.221-224 , 2014 .
AKM Mahbub Hasan, Hashimoto A, Maekawa Y, Matsumoto T, Kushima S, Ijiri TW, Fukami Y and Sato KI : The egg membrane microdomain-associated uroplakin III-Src system becomes functional during oocyte maturation and is required for bidirectional gamete signaling at fertilization in Xenopus laevis, Development , vol.141 , pp.1705-1714 , 2014 .
AKM Mahbub Hasan, ZH Mohammad and Hossain Uddin Shekhar : Lipid profile and renal function status in patients with hypothyroidism, J Bang Soc Pharm Professionals , vol.2 , no.II , pp.36-47 , 2013 .
MAUN Talukder, I Hossain, MMT Islam, AKM Mahbub Hasan and HU Shekhar : Determination of Functional Properties in Different Bangladeshi Fruits and Vegetables, Journal of Food Science and Engineering , vol.2 , no.9 , pp.48 , 2012 .
Ijiri TW, AKM Mahbub Hasan and Sato KI : Protein-tyrosine kinase signaling in the biological functions associated with sperm. Review, J Signal Transduct , vol.2012 , pp.181560 , 2012 .
AKM Mahbub Hasan, Ijiri T and Sato KI : Involvement of Src in the Adaptation of Cancer Cells under Microenvironmental Stresses. Review, J Signal Transduct , vol.2012 , pp.483796 , 2012 .
Shibib BA, Amin MA, AKM Mahbub Hasan and Rahman R : A creeper, Coccinia indica, has anti-hyperglycaemic and anti-ureogenic effects in diabetic rats, J Pak Med Assoc , vol.62 , no.11 , pp.1145-1148 , 2012 .
Uddin MM, Akteruzzaman S, Rahman T, AKM Mahbub Hasan and Shekhar HU : Pattern of beta-Thalassemia and Other Haemoglobinopathies: A Cross-Sectional Study in Bangladesh, ISRN Hematol , vol.2012 , pp.659191 , 2012 .
Kihira S, Yoshida J, Kawada Y, Hitomi Y, Asada TH, isatomi R, Ohta A, Iwasaki T, AKM Mahbub Hasan, Fukami Y and Sato KI : Membrane microdomain-associated uroplakin IIIa contributes to Src-dependent mechanisms of anti-apoptotic proliferation in human bladder carcinoma cells, Biol Open , vol.1 , no.10 , pp.1024-1034 , 2012 .
AKM Mahbub Hasan, Fukami Y and Sato KI : Gamete membrane microdomains and their associated molecules in fertilization signaling. Review, Mol Reprod Dev , vol.78 , no.10-11 , pp.814-30 , 2011 .
Lahiry G, Rahman T, AKM Mahbub Hasan, Dutta AK, Arif M and Howlader ZH : Assessment of Impact on Health of Children Working in the Garbage Dumping Site in Dhaka, Bangladesh, J Trop Pediatr , vol.57 , no.6 , pp.472-5 , 2011 .
Laisa A Lisa, Sabrina M Elias, M. Sazzadur Rahman, Saima Shahid, Tetsushi Iwasaki, AKM Mahbub Hasan, Keiko Kosuge, Yasuo Fukami and Seraj ZI : Physiology and gene expression of the rice landrace Horkuch under salt stress, Funct Plant Biol , vol.38 , no.4 , pp.282–292 , 2011 .
Kushima S, Mammadova G, AKM Mahbub Hasan, Fukami Y and Sato KI : Characterization of lipovitellin 2 as a tyrosine-phosphorylated protein in oocytes, eggs and early embryos of Xenopus laevis, Zoolog Sci , vol.28 , no.8 , pp.550-559 , 2011 .
Sabrina M Elias, AKM Mahbub Hasan and Seraj ZI : Microsatellite marker diversity and sequence polymorphism in the red gene locus of indigenous rice populations of Bangladesh, Plant Syst Evol , vol.296 , no.3-4 , pp.157-165 , 2011 .
Dipankar Das Gupta, Md. Enamul Haque, Md. Nahidul Islam, Shafiqur Rahman, AKM Mahbub Hasan and Baigid Alam Shibib : Alkaloid and Steroid from the Stem Bark of Jatropha curcas (Euphorbiaceae), Dhaka Univ J Pharm Sci , vol.10 , no.1 , pp.9-11 , 2011 .
Ferdaus MZ, AKM Mahbub Hasan and Shekhar HU : Analysis of serum lipid profiles, metal ions and thyroid hormones levels abnormalities in beta-thalassaemic children of Bangladesh, J Pak Med Assoc , vol.60 , no.5 , pp.360-4 , 2010 .
M Jakir H Howlader, M Arif, Ahmad F Karim, M Rakibul Islam and AKM Mahbub Hasan : Oxidative Stress and Antioxidant Status in Thyroid Dysfunction, Bangladesh J of Med Sci , vol.14 , no.1 , pp.52-6 , 2008 .
AKM Mahbub Hasan, Ou Z, Sakakibara K, Hirahara S, Iwasaki T, Sato KI and Fukami Y : Characterization of Xenopus egg membrane microdomains containing uroplakin Ib/III complex: roles of their molecular interactions for subcellular localization and signal transduction, Genes Cells , vol.12 , no.2 , pp.251-67 , 2007 .
Sakakibara K, Sato KI, Yoshino K, Oshiro N, Hirahara S, AKM Mahbub Hasan, Iwasaki T, Ueda Y, Iwao Y, Yonezawa K and Fukami Y : Molecular identification and characterization of Xenopus egg uroplakin III, an egg raft-associated transmembrane protein that is tyrosine-phosphorylated upon fertilization, J Biol Chem , vol.280 , no.15 , pp.15029-37 , 2005 .
AKM Mahbub Hasan, Sato KI, Sakakibara K, Ou Z, Iwasaki T, Ueda Y and Fukami Y : Uroplakin III, a novel Src substrate in Xenopus egg rafts, is a target for sperm protease essential for fertilization, Dev Biol , vol.286 , no.2 , pp.483-92 , 2005 .
Faruque SM, Rahman MM, AKM Mahbub Hasan, Nair GB, Mekalanos JJ and Sack DA : Diminished diarrheal response to Vibrio cholerae strains carrying the replicative form of the CTX(Φ) genome instead of CTX(Φ) lysogens in adult rabbits, Infect Immun , vol.69 , no.10 , pp.6084-90 , 2001 .
AKM Mahbub Hasan, Jahangir M, Rahim KA and Rahman M : Comparative study of mosquito larvicidal activity of locally isolated Bacillus sphaericus strains and commercially available ones, Bangladesh J Biochem , vol.6 , pp.69-74 , 2000 .
For PhD study.
|National||Faculty Gold Medal (Kamal Uddin Ahmed)||1996||Bangladesh||
For Excellency in MS.
|National||Jashore Board Merit Scholarship||1991||Bangladesh||
For excellency in HSC.
|National||Jashore Board Merit Scholarship||1989||Bangladesh||
For excellency in SSC.
|National||Jashore Board Merit Scholarship||1986||Bangladesh||
For excellency in Class VIII.